Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection

Enrolling by invitationOBSERVATIONAL
Enrollment

2,000

Participants

Timeline

Start Date

February 1, 2024

Primary Completion Date

December 31, 2024

Study Completion Date

January 31, 2025

Conditions
Helicobacter Pylori Infection
Interventions
DRUG

Bismuth Subcitrate

Tripotassium dicitratobismuthate 120 mg film-coated tablets. Prescribed for both primary and (potential) secondary treatment with bismuth-based quadruple therapy in participants with active H. pylori infection. The prescribed daily dose is 120 mg QID for a period of 14 days.

DRUG

Esomeprazole

Esomeprazol 40 mg gastro-resistant tablets or hard capsules. Which one of the three brands is prescribed for an individual participant in this prospective study depends on the decision of a chosen personal physician. Prescribed for both primary and (potential) secondary treatment with bismuth-based quadruple therapy in participants with active H. pylori infection. The prescribed daily dose is 40 mg BID for a period of 14 days.

DRUG

Metronidazole

Metronidazol 400 mg tablets. Prescribed for both primary and (potential) secondary treatment with bismuth-based quadruple therapy in participants with active H. pylori infection. The prescribed daily dose is 400 mg QID for a period of 14 days.

DRUG

Amoxicillin

Amoxicillin 500 mg dispersible tablets or hard capsules. Which one of the two brands is prescribed for an individual participant in this prospective study depends on the decision of a chosen personal physician. Prescribed only for the primary treatment with bismuth-based quadruple therapy in participants with active H. pylori infection who are not allergic to penicillin. The prescribed daily dose is 500 mg QID for a period of 14 days.

DRUG

Clarithromycin

Clarithromycin 500 mg film-coated tablets. Prescribed only for the primary treatment with bismuth-based quadruple therapy in participants with active H. pylori infection who are allergic to penicillin. The prescribed daily dose is 500 mg BID for a period of 14 days.

DRUG

Levofloxacin

Levofloxacin 500 mg film-coated tablets. Prescribed only for the (potential) secondary treatment with bismuth-based quadruple therapy in participants with active H. pylori infection. The prescribed daily dose is 500 mg OID for a period of 14 days.

Trial Locations (1)

2000

Community Healthcare Center dr. Adolf Drolc Maribor (HCM), Maribor

All Listed Sponsors
collaborator

Community Healthcare Center dr. Adolf Drolc Maribor (HCM)

OTHER

lead

National Institute of Public Health, Slovenia

OTHER_GOV