36
Participants
Start Date
August 15, 2025
Primary Completion Date
October 30, 2025
Study Completion Date
December 30, 2025
Sodium Chloride 0.9% Inj pre-exposure
Sterile normal saline 0.9% administered IV as a placebo immediately before hyperbaric chamber exposure
Sodium Chloride 0.9% Inj post-exposure
Sterile normal saline 0.9% administered IV as a placebo immediately after hyperbaric chamber exposure
Recombinant human plasma gelsolin pre-exposure
rhu-pGSN administered IV at a dose of 24 mg/kg immediately before hyperbaric chamber exposure
Recombinant human plasma gelsolin post-exposure
rhu-pGSN administered IV at a dose of 24 mg/kg immediately after hyperbaric chamber exposure
Hyperbaric chamber
High-pressure profile equivalent 35 minutes at a depth of 30 meters of sea water
University of Maryland School of Medicine, Baltimore
Lead Sponsor
BioAegis Therapeutics Inc.
INDUSTRY