Rhu-pGSN to Mitigate Proinflammatory Responses to Decompression in Healthy SCUBA Divers

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

August 15, 2025

Primary Completion Date

October 30, 2025

Study Completion Date

December 30, 2025

Conditions
Decompression Sickness
Interventions
DRUG

Sodium Chloride 0.9% Inj pre-exposure

Sterile normal saline 0.9% administered IV as a placebo immediately before hyperbaric chamber exposure

DRUG

Sodium Chloride 0.9% Inj post-exposure

Sterile normal saline 0.9% administered IV as a placebo immediately after hyperbaric chamber exposure

DRUG

Recombinant human plasma gelsolin pre-exposure

rhu-pGSN administered IV at a dose of 24 mg/kg immediately before hyperbaric chamber exposure

DRUG

Recombinant human plasma gelsolin post-exposure

rhu-pGSN administered IV at a dose of 24 mg/kg immediately after hyperbaric chamber exposure

OTHER

Hyperbaric chamber

High-pressure profile equivalent 35 minutes at a depth of 30 meters of sea water

Trial Locations (1)

21201

University of Maryland School of Medicine, Baltimore

Sponsors
All Listed Sponsors
lead

BioAegis Therapeutics Inc.

INDUSTRY