A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer.

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

71

Participants

Timeline

Start Date

February 19, 2024

Primary Completion Date

September 5, 2025

Study Completion Date

March 6, 2026

Conditions
Breast Cancer
Interventions
DRUG

vepdegestrant

Daily oral dosages of vepdegestrant continuously, dose escalation/de-escalation in Phase 1b until recommended phase 2 dose (RP2D) determined, cycles lasting 28 days

DRUG

PF-07220060

Daily oral dosages of PF-07220060 continuously, dose escalation/de-escalation in Phase 1b until recommended phase 2 dose (RP2D) determined, cycles lasting 28 days

Trial Locations (54)

1070

Institut Jules Bordet, Anderlecht

2650

Antwerp University Hospital, Edegem

3000

UZ Leuven, Leuven

8500

AZ Groeninge Campus Kennedylaan, Kortrijk

10022

Rockefeller Outpatient Pavilion (53rd Street), New York

10065

Evelyn H. Lauder Breast and Imaging Center (BAIC)., New York

Memorial Sloan Kettering Cancer Center, New York

10604

MSK Westchester, Harrison

11553

MSK Nassau, Uniondale

11725

MSK Commack, Commack

13273

Institut Paoli-Calmettes, Marseille

25198

Hospital Universitario Arnau de Vilanova de Lleida, Lleida

28041

Hospital Universitario 12 de Octubre, Madrid

34298

Institut Régional du Cancer Montpellier, Montpellier

41013

Hospital Universitario Virgen Del Rocio, Seville

44805

Institut de Cancérologie de l'Ouest, Saint-Herblain

49546

START Midwest, Grand Rapids

72703

Highlands Oncology, Fayetteville

72758

Highlands Oncology, Rogers

72762

Highlands Oncology Group, Springdale

78229

START San Antonio, San Antonio

80524

UCHealth Poudre Valley Hospital, Fort Collins

80528

UCHealth Harmony, Fort Collins

80538

UCHealth - Medical Center of the Rockies, Loveland

80634

UCHealth Greeley Hospital, Greeley

84112

Huntsman Cancer Institute, Salt Lake City

84119

START Mountain Region, West Valley City

92618

Hoag Health Center Irvine, Irvine

Hoag Hospital Irvine, Irvine

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

94158

UCSF Medical Center at Mission Bay, San Francisco

94304

Stanford Cancer Center, Palo Alto

Stanford Cancer Institute - Clinical Trials Office, Palo Alto

430023

Wuhan Union Hospital Cancer Center, Wuhan

510060

Sun Yat-sen University Cancer Center, Guangzhou

710061

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an

2418515

Kanagawa cancer center, Yokohama

06510

Smilow Cancer Hospital - Yale New Haven Health, New Haven

Yale - New Haven Hospital - Yale Cancer Center, New Haven

06511

Smilow Cancer Hospital Phase 1 Unit, New Haven

06611

Smilow Cancer Hospital - Trumbull, Trumbull

07920

MSK Basking Ridge, Basking Ridge

07748

MSK Monmouth, Middletown

07645

MSK Bergen, Montvale

K1H 8L6

The Ottawa Hospital - General Campus, Ottawa

M4N 3M5

Sunnybrook Research Institute, Toronto

M5G 2M9

Princess Margaret Cancer Centre, Toronto

277-8577

National Cancer Center Hospital East, Kashiwa

104-0045

National Cancer Center Hospital, Chuo-ku

142-8666

Showa Medical University Hospital, Tokyo

00680

BRCR Global - Mayaguez Administrative Office, Mayagüez

00682

BRCR Global - Mayagüez, Mayagüez

00935

Pan American Center for Oncology Trials, LLC, Rio Piedras

08035

Hospital Universitari Vall d'Hebron, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Arvinas Estrogen Receptor, Inc.

INDUSTRY

lead

Pfizer

INDUSTRY

NCT06206837 - A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer. | Biotech Hunter | Biotech Hunter