PD-1 Antibody Plus Bevacizumab and CAPOX as First-line Treatment for RAS-mut MSS mCRC

PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

May 26, 2021

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2025

Conditions
Colorectal CancerRAS MutationColorectal NeoplasmsMicrosatellite Stable Colorectal Carcinoma
Interventions
DRUG

oxaliplatin+capecitabine+bevacizumab+PD-1 antibody

oxaliplatin will be administered once every 3 weeks at a dose of 130 mg/m2; Capecitabine will be taken orally at a dose of 1g/m2 twice daily for continuous oral administration over 14 days; Bevacizumab will be administered intravenously every 3 weeks at a dose of 7.5 mg/kg; PD-1 antibody was given due to different types.

Trial Locations (1)

100853

RECRUITING

Chinese PLA General Hospital, Beijing

All Listed Sponsors
lead

Chinese PLA General Hospital

OTHER