18
Participants
Start Date
February 14, 2024
Primary Completion Date
July 1, 2024
Study Completion Date
July 1, 2025
Implantable Micro-Device
The implantable microdevice will release microdoses of specific drugs or drug combinations as a possible tool to evaluate the effectiveness of several cancer drugs against bladder cancer.
Methotrexate
Methotrexate will be placed in reservoir 1 of the implantable microdevice.
Carboplatin
Carboplatin will be placed in reservoir 2 of the implantable microdevice.
Avelumab
Avelumab will be placed in reservoir 3 of the implantable microdevice.
Paclitaxel
Paclitaxel will be placed in reservoir 4 of the implantable microdevice.
Vinblastine
Vinblastine will be placed in reservoir 5 of the implantable microdevice.
Gemcitabine/Cisplatin I
Gemcitabine/Cisplatin will be placed in reservoir 6 of the implantable microdevice.
Methotrexate/Vinblastine/Doxorubicin/Cisplatin/Avelumab
(Methotrexate/Vinblastine/Doxorubicin/Cisplatin/Avelumab) will be placed in reservoir 7 of the implantable microdevice.
Gemcitabine/Cisplatin II
Gemcitabine/Cisplatin will be placed in reservoir 8 of the implantable microdevice.
Cisplatin
Cisplatin will be placed in reservoir 9 of the implantable microdevice.
Nivolumab
Nivolumab will be placed in reservoir 10 of the implantable microdevice.
Pembrolizumab
Pembrolizumab will be placed in reservoir 11 of the implantable microdevice.
Gemcitabine/Carboplatin
Gemcitabine/Carboplatin will be placed in reservoir 12 of the implantable microdevice.
Methotrexate/Vinblastine/Doxorubicin/Cisplatin
(Methotrexate/Vinblastine/Doxorubicin/Cisplatin) will be placed in reservoir 13 of the implantable microdevice.
Gemcitabine/Cisplatin/Nivolumab
(Gemcitabine/Cisplatin/Nivolumab) will be placed in reservoir 14 of the implantable microdevice.
Erdafitinib
Erdafitinib will be placed in reservoir 15 of the implantable microdevice.
Paclitaxel/Docetaxel/Ifosfamide
(Paclitaxel/Docetaxel/Ifosfamide) will be placed in reservoir 16 of the implantable microdevice.
Gemcitabine
Gemcitabine will be placed in reservoir 17 of the implantable microdevice.
Gemcitabine/Carboplatin/Nivolumab
(Gemcitabine/Carboplatin/Nivolumab) will be placed in reservoir 18 of the implantable microdevice.
Enfortumab
Enfortumab will be placed in reservoir 19 of the implantable microdevice.
Sacituzumab
Sacitzumab will be placed in reservoir 20 of the implantable microdevice.
Brigham and Women's Hospital, Boston
Brigham and Women's Hospital
OTHER