Drug Screening Using IMD in Bladder Cancer

EARLY_PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

February 14, 2024

Primary Completion Date

July 1, 2024

Study Completion Date

July 1, 2025

Conditions
Muscle Invasive Bladder Urothelial Carcinoma
Interventions
DEVICE

Implantable Micro-Device

The implantable microdevice will release microdoses of specific drugs or drug combinations as a possible tool to evaluate the effectiveness of several cancer drugs against bladder cancer.

DRUG

Methotrexate

Methotrexate will be placed in reservoir 1 of the implantable microdevice.

DRUG

Carboplatin

Carboplatin will be placed in reservoir 2 of the implantable microdevice.

DRUG

Avelumab

Avelumab will be placed in reservoir 3 of the implantable microdevice.

DRUG

Paclitaxel

Paclitaxel will be placed in reservoir 4 of the implantable microdevice.

DRUG

Vinblastine

Vinblastine will be placed in reservoir 5 of the implantable microdevice.

DRUG

Gemcitabine/Cisplatin I

Gemcitabine/Cisplatin will be placed in reservoir 6 of the implantable microdevice.

DRUG

Methotrexate/Vinblastine/Doxorubicin/Cisplatin/Avelumab

(Methotrexate/Vinblastine/Doxorubicin/Cisplatin/Avelumab) will be placed in reservoir 7 of the implantable microdevice.

DRUG

Gemcitabine/Cisplatin II

Gemcitabine/Cisplatin will be placed in reservoir 8 of the implantable microdevice.

DRUG

Cisplatin

Cisplatin will be placed in reservoir 9 of the implantable microdevice.

DRUG

Nivolumab

Nivolumab will be placed in reservoir 10 of the implantable microdevice.

DRUG

Pembrolizumab

Pembrolizumab will be placed in reservoir 11 of the implantable microdevice.

DRUG

Gemcitabine/Carboplatin

Gemcitabine/Carboplatin will be placed in reservoir 12 of the implantable microdevice.

DRUG

Methotrexate/Vinblastine/Doxorubicin/Cisplatin

(Methotrexate/Vinblastine/Doxorubicin/Cisplatin) will be placed in reservoir 13 of the implantable microdevice.

DRUG

Gemcitabine/Cisplatin/Nivolumab

(Gemcitabine/Cisplatin/Nivolumab) will be placed in reservoir 14 of the implantable microdevice.

DRUG

Erdafitinib

Erdafitinib will be placed in reservoir 15 of the implantable microdevice.

DRUG

Paclitaxel/Docetaxel/Ifosfamide

(Paclitaxel/Docetaxel/Ifosfamide) will be placed in reservoir 16 of the implantable microdevice.

DRUG

Gemcitabine

Gemcitabine will be placed in reservoir 17 of the implantable microdevice.

DRUG

Gemcitabine/Carboplatin/Nivolumab

(Gemcitabine/Carboplatin/Nivolumab) will be placed in reservoir 18 of the implantable microdevice.

DRUG

Enfortumab

Enfortumab will be placed in reservoir 19 of the implantable microdevice.

DRUG

Sacituzumab

Sacitzumab will be placed in reservoir 20 of the implantable microdevice.

Trial Locations (1)

02115

Brigham and Women's Hospital, Boston

All Listed Sponsors
lead

Brigham and Women's Hospital

OTHER

NCT06204614 - Drug Screening Using IMD in Bladder Cancer | Biotech Hunter | Biotech Hunter