Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

December 1, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Long Haul COVID-19Post-Acute COVID-19 SyndromeAnosmiaOlfaction Disorders
Interventions
DRUG

Sodium Citrate

Those randomized to the Sodium Citrate arm will use 1 mL of 2.5% sodium citrate (3.5g/140 mL, pH 7.4, 298 mOsmol/L), 0.5 mL in each nostril, twice a day via an atomizer followed by olfactory training.

DRUG

Normal Saline

Those randomized to the Normal Saline arm will use 1 mL of normal saline, 0.5 mL in each nostril, twice a day via an atomizer followed by olfactory training.

OTHER

"Olfactory Training Kit - The Olfactory Kit, by AdvancedRx"

All participants, regardless of study arm they are randomized to, will participate in olfactory training twice a day after use of their nasal spray

Trial Locations (1)

27599

University of North Carolina at Chapel Hill, Chapel Hill

All Listed Sponsors
lead

University of North Carolina, Chapel Hill

OTHER

NCT06204432 - Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction | Biotech Hunter | Biotech Hunter