142
Participants
Start Date
May 13, 2024
Primary Completion Date
October 30, 2024
Study Completion Date
October 30, 2025
avatrombopag
The avatrombopag 20mg/d will be orally taken from +D7 after haplo-HSCT until meeting the adjustment indication or to +D60 after haplo-HSCT; When PLT\<50×10\^9/L or PLT transfusion-dependent on the +D30 after haplo-HSCT, increase avatrombopag dosage to 40 mg/d; When PLT≥80×10\^9/L and without PLT transfusion within avatrombopag dosage at 40 mg/d, decrease avatrombopag dosage to 20 mg/d; When PLT≥80×10\^9/L for 7 consecutive days or PLT≥300×10\^9/L and without PLT transfusion, stop avatrombopag; When PLT\<50×10\^9/L or PLT transfusion-dependent after stopping avatrombopag , reuse avatrombopag at 40 mg/d.
Placebo
The placebo 20mg/d will be orally taken from +D7 after haplo-HSCT until meeting the adjustment indication or to +D60 after haplo-HSCT; When PLT\<50×10\^9/L or PLT transfusion-dependent on the +D30 after haplo-HSCT, increase placebo dosage to 40 mg/d; When PLT≥80×10\^9/L and without PLT transfusion within placebo dosage at 40 mg/d, decrease placebo dosage to 20 mg/d; When PLT≥80×10\^9/L for 7 consecutive days or PLT≥300×10\^9/L and without PLT transfusion, stop placebo; When PLT\<50×10\^9/L or PLT transfusion-dependent after stopping placebo, reuse placebo at 40 mg/d.
RECRUITING
Peking University People's Hospital, Beijing
NOT_YET_RECRUITING
Xiangya Hospital, Central South University, Changsha
NOT_YET_RECRUITING
920th Hospital of Joint Logistics Support Force of People's Liberation Army of China, Kunming
NOT_YET_RECRUITING
Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou
RECRUITING
Peking University Shenzhen Hospital, Shenzhen
NOT_YET_RECRUITING
The First Affiliated Hospital, Harbin Medical University, Harbin
NOT_YET_RECRUITING
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
NOT_YET_RECRUITING
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
NOT_YET_RECRUITING
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
NOT_YET_RECRUITING
The First Affiliated Hospital of Nanchang University, Nanchang
NOT_YET_RECRUITING
Shanxi Tumor Hospital Affiliated to Shanxi Medical University, Taiyuan
NOT_YET_RECRUITING
Tangdu Hospital, PLA Air Force Military Medical University, Xi’an
NOT_YET_RECRUITING
Xinqiao Hospital, Army Military Medical University, Chongqing
NOT_YET_RECRUITING
Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin
Xiangya Hospital of Central South University
OTHER
Sichuan Provincial People's Hospital
OTHER
First Affiliated Hospital of Harbin Medical University
OTHER
The First Affiliated Hospital of Zhengzhou University
OTHER
First Affiliated Hospital of Xinjiang Medical University
OTHER
Shanxi Bethune Hospital
OTHER
920th Hospital of Joint Logistics Support Force of People's Liberation Army of China
OTHER
Tang-Du Hospital
OTHER
The First Affiliated Hospital of Nanchang University
OTHER
Peking University People's Hospital
OTHER