Ketones in Heart Failure With Reduced Ejection Fraction

PHASE2Enrolling by invitationINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

March 6, 2024

Primary Completion Date

February 28, 2027

Study Completion Date

February 28, 2027

Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
DIETARY_SUPPLEMENT

ketone ester

500 mg/kg of ketone ester administered approximately 1 hour prior to the maximal exercise testing and 250 mg/kg administered approximately 30 minutes prior to submaximal exercise testing

DIETARY_SUPPLEMENT

placebo

ketone-free placebo administered approximately 1 hour prior to the maximal exercise testing and ketone-free placebo administered approximately 30 minutes prior to submaximal exercise testing

Trial Locations (1)

27710

Duke University, Durham

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

American Heart Association

OTHER

collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Duke University

OTHER