DEB-TACE, Lenvatinib and Anti-PD(L)1 Antibody as Conversion Therapy for Intrahepatic Cholangiocarcinoma

RecruitingOBSERVATIONAL
Enrollment

100

Participants

Timeline

Start Date

February 1, 2022

Primary Completion Date

December 31, 2024

Study Completion Date

June 30, 2025

Conditions
Cholangiocarcinoma Non-resectable
Interventions
PROCEDURE

drug eluting beads-transcatheter arterial chemoembolization

transcatheter arterial chemoembolization with doxorubicin embedded eluting beads- was performed every 3 weeks through the tumor feeding arteries.

DRUG

envatinib plus anti-PD(L)1

oral use of lenvatinib plus intravenous injection of anti-PD(L)1 antibodies. Anti-PD-L1 antibodies includes duravalumab, atezolizumab, or envolizumab, and anti-PD1 antibodies include pembrolizumab, nivolumab, camrelizumab, tislelizumab, sintilimab, or toripalimab.

Trial Locations (1)

430030

RECRUITING

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

All Listed Sponsors
collaborator

Geneplus-Beijing Co. Ltd.

INDUSTRY

collaborator

Chinese Cooperative Group of Liver Cancer

OTHER

lead

Ze-yang Ding, MD

OTHER