Evaluate the Neurological Effects of EryDex on Subjects With A-T

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

June 24, 2024

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Ataxia Telangiectasia
Interventions
DRUG

Dexamethasone sodium phosphate

Dexamethasone sodium phosphate encapsulated in autologous erythrocytes and administered via IV infusion

OTHER

Placebo

Placebo encapsulated in autologous erythrocytes and administered via IV infusion

Trial Locations (19)

2100

Copenhagen University Hospital, Rigshospitalet, Department of Pediatric Neurology, Copenhagen

21289

The Johns Hopkins Hospital, Division of pediatric allergy and immunology, Baltimore

25123

Spedali Civili di Brescia, Pediatric immunology department, Brescia

28046

Hospital Universitario La Paz, Department of pediatric neurology, Madrid

45229

Cincinnati Children's Hospital, Division of neurology, Cincinnati

60590

University Hospital Frankfurt, Pediatric and Adolescent Clinic, Frankfurt

60596

IKF Pneumologie GmbH & Co. KG; Institut für klinische Forschung Pneumologie Clinical Research Center Respiratory Diseases, Frankfurt

77030

UT Health Houston, Department of pediatrics, division of child & adolescent neurology, Houston

90095

University of California Los Angeles (UCLA), Ataxia Center and HD Center of excellence, Los Angeles

00161

Policlinico Umberto I, La sapienza University, Department of neurosciences and menthal health, Roma

0372

Oslo University Hospital, Rikshospitalet, Division of Pediatric and Adolescent Medicine, Norwegian National Unit for Newborn Screening, Oslo

60-693

MedPolonia sp zoo, Poznan

04-736

"Instytut Pomnik-Centrum Zdrowia Dziecka, Immunology clinic", Warsaw

08035

Hospital Universitari Vall d'Hebron, Department of pediatric neurology, Barcelona

CH-8008

University Children's Hospital Zürich - Eleonore Foundation, Zurich

B152GW

University Hospitals Birmingham NHS Foundation Trust, Birmingham

SW17 0RE

St George's University Hospitals NHS Foundation Trust, Centre for Neonatal and Paediatric Infection, London

WC1N 1DZ

Great Ormond Street Hospital for Children, Zayed Centre for Research, London

NG7 2UH

Nottingham Children's Hospital, Queen's Medical Center, Children's neurology, Nottingham

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Biotrial

INDUSTRY

lead

Quince Therapeutics S.p.A.

INDUSTRY

NCT06193200 - Evaluate the Neurological Effects of EryDex on Subjects With A-T | Biotech Hunter | Biotech Hunter