Optimize First-line Treatment for AL Amyloidosis With t (11; 14)

NARecruitingINTERVENTIONAL
Enrollment

41

Participants

Timeline

Start Date

January 5, 2024

Primary Completion Date

December 31, 2025

Study Completion Date

June 30, 2026

Conditions
Amyloidosis; SystemicAL Amyloidosis
Interventions
DRUG

Daratumumab

"Daratumumab 16 mg/kg was administered intravenously weekly in cycles one and two, every two weeks for cycles three to six, for at least 6 cycles.~Daratumumab and hyaluronidase-fihj 1800mg is allowed according to the patients' choice."

DRUG

Bortezomib

All patients received 1.0-1.3 mg/m2 subcutaneous bortezomib once weekly of 28 days each for at 6 cycles.

DRUG

Dexamethasone

All patients received 20-40 mg oral or intravenous dexamethasone

DRUG

Venetoclax

All patients received venetoclax 400mg daily.

Trial Locations (1)

100044

RECRUITING

Peking University People's Hospital, Beijing

All Listed Sponsors
lead

Jin Lu, MD

OTHER