Clinical Study to Evaluate Cannabidiol Liver Enzyme Elevations and Drug Interactions

Cannabidiol (Epidiolex) will be administered orally 2.5 mg/kg twice daily (5 mg/kg/day) for 28 days in Part 1 and for 9 days (morphine cohort) or 12 days (citalopram cohort) in Part 2.

Placebo will be administered orally twice daily for 28 days in Part 1

Citalopram (Celexa) will be administered once at 20 mg on days 1 and 13.

Morphine will be administered once at 15 mg on days 1, 4, and 11.