315
Participants
Start Date
March 11, 2025
Primary Completion Date
March 11, 2026
Study Completion Date
March 11, 2027
Isoniazid
INH 300 mg will be administered as one tablet orally once daily.
Rifampicin
RIF 600 mg will be administered as two 300 mg capsules orally once daily on an empty stomach, 1 hour before or 2 hours after eating a meal.
Pyrazinamide
PZA will be administered as 500 mg tablets, based on weight, orally once daily.
Ethambutol
EMB will be administered as 400 mg tablets, based on weight, orally once daily.
Bedaquiline
BDQ 400 mg will be administered as four 100 mg tablets orally once daily with a meal for the first 2 weeks followed by 200 mg (two 100 mg tablets) orally once daily with a meal for 6 weeks.
Pretomanid
Pa 200 mg will be administered as one 200 mg tablet orally once daily with a meal.
Linezolid
LZD 600 mg will be administered as one 600 mg tablet orally once daily.
TBI-223
TBI-223 2400 mg once daily will be administered as four 600 mg tablets orally once daily with a meal.
Sutezolid
SZD 1600 mg once daily will be administered as four 400 mg tablets orally once daily with a meal.
TBI-223
TBI-223 1200 mg once daily will be administered as two 600 mg tablets orally with a meal.
Sutezolid
SZD 800 mg once daily will be administered as two 400 mg tablets orally once daily with a meal.
NOT_YET_RECRUITING
30301, Blantyre CRS, Blantyre
NOT_YET_RECRUITING
11301, Barranco CRS, Lima
NOT_YET_RECRUITING
12301, Soweto ACTG CRS, Johannesburg
NOT_YET_RECRUITING
11101, University of the Witwatersrand Helen Joseph (WITS HJH) CRS, Johannesburg
NOT_YET_RECRUITING
11201, Durban International CRS, Durban
NOT_YET_RECRUITING
31981, TB HIV Innovations and Clinical Research Foundation Corp., Cavite
NOT_YET_RECRUITING
30022, Les Centres GHESKIO Clinical Research Site (GHESKIO-INLR) CRS, Port-au-Prince
NOT_YET_RECRUITING
31730, GHESKIO Institute of Infectious Diseases and Reproductive Health (GHESKIO - IMIS) CRS, Port-au-Prince
RECRUITING
31793, South African Tuberculosis Vaccine Initiative (SATVI) CRS, Cape Town
NOT_YET_RECRUITING
31792, University of Cape Town Lung Institute (UCTLI) CRS, Cape Town
NOT_YET_RECRUITING
12401, Joint Clinical Research Centre (JCRC)/Kampala CRS, Kampala
NOT_YET_RECRUITING
31802, Thai Red Cross AIDS Research Centre (TRC-ARC) CRS, Pathum Wan
NOT_YET_RECRUITING
32078, Nutrición-Mexico CRS, Mexico City
NOT_YET_RECRUITING
31985, Socios En Salud Sucursal Perú CRS, Lima
RECRUITING
12501, Kenya Medical Research Institute/Walter Reed Project Clinical Research Center (KEMRI/WRP) CRS, Kericho
RECRUITING
12101, Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS, Rio de Janeiro
NOT_YET_RECRUITING
12601, Moi University Clinical Research Center (MUCRC) CRS, Eldoret
NOT_YET_RECRUITING
30313, Milton Park CRS, Harare
NOT_YET_RECRUITING
31422, CAPRISA eThekwini CRS, Durban
NOT_YET_RECRUITING
31784, Chiang Mai University HIV Treatment (CMU HIV Treatment) CRS, Chiang Mai
NOT_YET_RECRUITING
5116 Chiangrai Prachanukroh Hospital NICHD CRS, Chiang Rai
NOT_YET_RECRUITING
12201, Hospital Nossa Senhora da Conceicao CRS, Porto Alegre
NOT_YET_RECRUITING
32483 National Lung Hospital CRS, Hanoi
NOT_YET_RECRUITING
31441, Byramjee Jeejeebhoy Medical College (BJMC) CRS, Pune
NOT_YET_RECRUITING
12701, Gaborone CRS, Gaborone
NOT_YET_RECRUITING
12001, Malawi CRS, Lilongwe
RECRUITING
31684, Rustenburg CRS, Rustenburg
TB Alliance
UNKNOWN
National Institute of Allergy and Infectious Diseases (NIAID)
NIH