Prophylactic Antibiotics in Cystectomy With Diversion

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

May 13, 2024

Primary Completion Date

October 15, 2026

Study Completion Date

October 15, 2026

Conditions
Muscle-Invasive Bladder CarcinomaRadical CystectomyIleal ConduitNeobladder Diversion
Interventions
DRUG

Prophylactic antibiotics postoperatively.

Prophylactic antibiotics postoperatively. All participants in this arm will receive nitrofurantoin 100 milligrams by mouth daily for either 10 or 21 days based on whether they had an ileal conduit or orthotopic neobladder, respectively, for the diversion. Participants will be instructed to swallow the capsule whole, preferably with food and at the same time each day. If a dose is forgotten, participants will be asked to take it when they remember and then take the next dose as usual. However, if they do not remember until the next dose, do not take extra capsules to make up the missed dose.

Trial Locations (1)

55414

RECRUITING

University of Minnesota, Minneapolis

All Listed Sponsors
lead

University of Minnesota

OTHER