NCT06188923View on ClinicalTrials.gov

A New Intervention to Improve Function in Veterans With Anxiety and Depression

PHASE2RecruitingINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

August 14, 2025

Primary Completion Date

June 30, 2028

Study Completion Date

September 30, 2028

Conditions
Anxiety and Depression
Interventions
DRUG

Pregnenolone

Pregnenolone 250 mg BID x 14 DAYS, followed by Pregnenolone 500 mg BID x 14 DAYS, followed by Pregnenolone 1000 mg BID x thereafter for the remainder of the 8-week trial.

DRUG

Placebo

Same as active comparator, except placebo dispensed

Trial Locations (1)

27705-3875

RECRUITING

Durham VA Medical Center, Durham, NC, Durham

All Listed Sponsors
lead

VA Office of Research and Development

FED