BrighT STAR LIBRA: Leveraging Implementation Science for Blood Culture Reduction Approaches

NAActive, not recruitingINTERVENTIONAL
Enrollment

8

Participants

Timeline

Start Date

January 1, 2023

Primary Completion Date

October 31, 2025

Study Completion Date

March 31, 2026

Conditions
Blood Culture RatesAntibiotic StewardshipImplementation Science
Interventions
BEHAVIORAL

Checklist

This intervention consists of a checklist to guide blood culture decisions, that a clinician in a site randomized to Arm A will be asked to consult and complete prior to ordering or not ordering a blood culture; as the relevant clinical scenario occurs. Meaning, if a clinician in Arm A is faced with a scenario in which it is customary or usual care to consider a blood culture, the clinician will be asked to first review this checklist. The checklist is not a binding or absolute process - the clinician should use both the checklist and typical clinical judgment to decide if the blood culture test is needed or not. The checklist is based on prototypes used in the completed parent study, BrighT STAR and the earlier preliminary studies at Johns Hopkins.

BEHAVIORAL

Targeted Messaging

This intervention consists of targeted messaging and education that the primary study team will create and ask the Arm B sites to deliver to the PICU clinicians, which focuses on the importance of diagnostic stewardship and the current evidence for the benefit/low risk nature of the stewardship program to date.

Trial Locations (8)

10019

Kravis Children's Hospital, New York

10032

New York-Presbyterian Morgan Stanley Children's Hospital, New York

19803

Nemours / AI DuPont Hospital for Children, Wilmington

40202

Norton Children's Hospital, Louisville

46202

Riley Hospital for Children, Indianapolis

53201

Children's Hospital of Wisconsin, Milwaukee

90095

UCLA Mattel Children's Hospital, Los Angeles

94158

UCSF Benioff Children's Hospital Mission Bay, San Francisco

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

Johns Hopkins University

OTHER

lead

Children's Hospital of Philadelphia

OTHER