Treatment of Newly Diagnosed High Risk Pediatric Acute Lymphoblastic Leukemia

"Intervention Description :~* Clinical and genetic factors consistent with High risk : Induction → Consolidation~ 1. BM MRD \&lt; 0.01% after both Induction and Consolidation : IM #1 → DI #1 → IM #2 → Maintenance~ 2. BM MRD ≥ 0.01% after Induction, \&lt; 0.01% after Consolidation : IM #1 → DI #1 → IM #2 → DI #2 → Maintenance~ 3. BM MRD ≥ 0.01% after Consolidation~ <!-- -->~ 1. T cell ALL : Change to very high risk regimen~ 2. Pre-B ALL : IM #1 → Intensification~ 1. BM MRD \&lt; 0.01% after IM #1 : Continue with \&#39;No. 2\&#39; of High risk regimen starting with DI #1~ 2. BM MRD ≥ 0.01% after IM #1 : Change to Very high risk regimen~ * T cell ALL patients with M1 BM post-Consolidation will start IM #1. However, the patients will switch to Very high risk regimen at the next chemotherapy cycle once post-Consolidation MRD ≥ 0.01% has been reported."