Treatment Protocol for Newky Diagnosed Adult Ph Positive ALL

dose 1.5 mg/m2 at days 1, 8, 15 and 22

40 mg on days 1-2, 8-9,15-16 and 22-23

600 mg per day from 1 to up to 5 years

1000 mg/m2/ on days 1, 3 and 5 of consolidation with 2h infusion

50 mg/m2 on days 1 to 28 of maintenance

1000 mg/m2 on day 1 of consolidation with 24h infusion; and 20 mg/m2 on days 1, 8, 15 and 22 of maintenance

15 mg per day from consolidation start up to 5 years

Allogeneic stem cell transplantation from hematpoietic stem cells progenitors of familiar or not familiar origin. Cord blood transplantation can also be done.

Fractionated dose with total dose of 12 Gy between days -4 and -1 of allogeneic stem cell transplantation (alloSCT)

60 mg/kg on days -6 and -5 before alloSCT

30 mg/m2 intravenous on days -7, -6, -5 y -4 before alloSCT (alternative to cyclophosphamide)