Safety and Efficacy of Thermosensitive Hydroxybutyl Chitosan and 5-fluorouracil Assisted Endoscopic Dacryocystorhinostomy in the Treatment of Chronic Dacryocystitis

PHASE1CompletedINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

December 3, 2021

Primary Completion Date

June 30, 2023

Study Completion Date

December 3, 2023

Conditions
DacryocystorhinostomyHydroxybutyl ChitosanFluorouracilChronic Dacryocystitis
Interventions
DRUG

Hydroxybutyl chitosan

Apply HBCS to the anastomosis of the nasal mucosal flap and the dacryocyst mucosal flap

DRUG

5-Fluorouracil

Inject 0.3ml of 5-FU solution (25mg/ml) into the nasal mucosa around the anastomosis, and apply HBCS to the anastomosis of the nasal mucosal flap and the dacryocyst mucosal flap

DRUG

Gelatin Sponge Sheet

Apply gelatin sponge sheet covered with thrombin and tobramycin and dexamethasone ophthalmic ointment to the anastomosis of nasal mucosal flap and dacryocyst mucosal flap

Trial Locations (1)

Unknown

Limin Zhu, Tianjin

All Listed Sponsors
lead

Tianjin Medical University Eye Hospital

OTHER

NCT06175676 - Safety and Efficacy of Thermosensitive Hydroxybutyl Chitosan and 5-fluorouracil Assisted Endoscopic Dacryocystorhinostomy in the Treatment of Chronic Dacryocystitis | Biotech Hunter | Biotech Hunter