Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy

PHASE2RecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

March 21, 2025

Primary Completion Date

February 1, 2027

Study Completion Date

July 1, 2027

Conditions
Arrhythmogenic CardiomyopathyArrhythmogenic Right Ventricular Cardiomyopathy
Interventions
DRUG

Tideglusib

Tideglusib 1g po daily

DRUG

Placebo

Matching placebo 1g po daily

Trial Locations (17)

T2N 2T9

NOT_YET_RECRUITING

Foothills Medical Centre, Calgary

V6Z 1Y6

NOT_YET_RECRUITING

St. Paul's Hospital, Vancouver

V8Z 0B9

RECRUITING

Victoria Cardiac Arrhythmia Trials Inc., Victoria

A1B 3V6

NOT_YET_RECRUITING

Health Sciences Centre, St. John's

B3H 2Y9

NOT_YET_RECRUITING

Queen Elizabeth II Health Sciences Centre, Halifax

L8L 2X2

RECRUITING

Hamilton General Hospital, Hamilton

K7L 2V7

NOT_YET_RECRUITING

Kingston General Hospital, Kingston

N6A 5A5

RECRUITING

London Health Sciences Centre, London

L3Y 2P9

NOT_YET_RECRUITING

Newmarket Electrophysiologist Research Group 'NERG', Newmarket

K1Y 4W7

NOT_YET_RECRUITING

University of Ottawa Heart Institute, Ottawa

M1E 4B9

RECRUITING

Heart Health Institute Research Inc, Scarborough Village

M4N 3M5

NOT_YET_RECRUITING

Sunnybrook Health Sciences Centre, Toronto

M5B 1W8

NOT_YET_RECRUITING

St. Michael's Hospital, Toronto

H1T 1C8

RECRUITING

Montreal Heart Institute, Montreal

H4A 3J1

NOT_YET_RECRUITING

McGill University Health Centre, Montreal

H4J 1C5

NOT_YET_RECRUITING

Hopital du Sacré-Coeur de Montréal, Montreal

G1V 4G5

RECRUITING

University Institute of Cardiology and Pneumology of Quebec, Québec

All Listed Sponsors
collaborator

Population Health Research Institute

OTHER

collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

collaborator

AMO Pharma

UNKNOWN

collaborator

Hearts in Rhythm Organization (HiRO)

UNKNOWN

collaborator

Canadian SADS

UNKNOWN

lead

Hamilton Health Sciences Corporation

OTHER