Ramucirumab Combined With Nab-paclitaxel, Lobaplatin, and S-1 in Neoadjuvant Transformation Therapy for Advanced Gastric Cancer

PHASE4RecruitingINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

December 30, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Advanced Gastric Cancer
Interventions
DRUG

nab-paclitaxel, lobaplatin, and S-1 combined with ramucirumab

Patients in Experimental group will be given ramucirumab (8mg/kg) by intravenous drip on the first day of each cycle, 3 weeks a cycle.

DRUG

nab-paclitaxel, lobaplatin, and S-1

Patients will be given lobaplatin (30 mg/m2) and nab-paclitaxel (100mg/m2) by intravenous drip on the first day of each cycle, 3 weeks a cycle, together with oral S-1 (patients with a body surface area less than 1.25 m2, will give 40 mg each time. Patients with a body surface area between 1.25 and 1.5 m2; will give 50 mg each time; patients with a body surface area greater than 1.5 m2, will give 60 mg each time), 2 weeks on and 1 week off.

Trial Locations (1)

Unknown

RECRUITING

The First Affiliated Hospital of the Air Force Medical University, Xi'an

All Listed Sponsors
lead

Yang Jianjun, PhD

OTHER