Efficacy of 5-fluorouracil and Low Molecular Weight Heparin in High-risk Pediatric Retinal Detachment

NACompletedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

October 21, 2021

Primary Completion Date

October 21, 2022

Study Completion Date

May 21, 2023

Conditions
Retinal DetachmentProliferative Vitreoretinopathy
Interventions
DRUG

Intraoperative infusion of 5-FU (200 µg/ml) and LMWH (5 IU/ml)

After informed consent, children under 14 years of age with high-risk PRRD underwent pars plana vitrectomy and silicone oil injection with scleral buckle divided into 2 groups in prospective randomized trial. Group A received intraoperative infusion of 5-FU (200 µg/ml) and LMWH (5 IU/ml).

DRUG

Placebo

After informed consent, children under 14 years of age with high-risk PRRD underwent pars plana vitrectomy and silicone oil injection with scleral buckle divided into 2 groups in prospective randomized trial. Group B received infusion of normal saline.

Trial Locations (1)

Unknown

Faculty of Medicine, Alexandria University, Alexandria

All Listed Sponsors
lead

Alexandria University

OTHER

NCT06166914 - Efficacy of 5-fluorouracil and Low Molecular Weight Heparin in High-risk Pediatric Retinal Detachment | Biotech Hunter | Biotech Hunter