Study of BEBT-908 Combined With Drugs in the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

PHASE1RecruitingINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

December 1, 2023

Primary Completion Date

October 31, 2025

Study Completion Date

November 5, 2025

Conditions
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Interventions
DRUG

BEBT-908 for Injection

BEBT-908 for Injection,dosage of administration:15mg/m\^2 or 22.5mg/m\^2,frequency and duration of administration:on the 1st,3rd,5th,8th,10th and 12th days of each cycle,and 21 days as a cycle.

DRUG

Rituximab Injection

Rituximab Injection,dosage of administration:375 mg/m\^2,frequency and duration of administration:on the 1st day of each cycle, and 21 days as a cycle.

DRUG

Gemcitabine Hydrochloride for Injection

Gemcitabine Hydrochloride for Injection,dosage of administration:1g/m\^2,frequency and duration of administration:on the 2nd day of each cycle, and 21 days as a cycle.

DRUG

Oxaliplatin Injection

Oxaliplatin Injection,dosage of administration:100mg/m\^2,frequency and duration of administration:on the 2nd day of each cycle, and 21 days as a cycle.

DRUG

Etoposide Injection

Etoposide Injection,dosage of administration:100mg/m\^2,frequency and duration of administration:on the 1st,2nd and 3rd days of each cycle,and 21 days as a cycle.

DRUG

Ifosfamide for Injection

Ifosfamide for Injection,dosage of administration:5000mg/m\^2,24 hours of continuous intravenous drip,frequency and duration of administration:on the 2nd day of each cycle, and 21 days as a cycle.

DRUG

Carboplatin Injection

Carboplatin Injection,dosage of administration:based on AUC=5, single dose ≤800 mg,frequency and duration of administration:on the 2nd day of each cycle, and 21 days as a cycle.

Trial Locations (1)

100021

RECRUITING

Cancer Hospital Chinese Academy of Medical Sciences, Beijing

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeBetter Med Inc

INDUSTRY