NCT06160284View on ClinicalTrials.gov

Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)

PHASE1RecruitingINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

May 28, 2025

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Opioid Use Disorder
Interventions
DRUG

Psilocybin

Participants will receive a single dose of psilocybin administered in 20 mg or 25 mg doses depending on the participant's weight: 20 mg (among participants \< 70 kg) or 25 mg (among participants \>70 kg). Participants will be administered psilocybin at CNRU, within 1-2 weeks of the baseline \[11C\]-UCB-J PET.

Trial Locations (1)

06520

RECRUITING

Yale University, New Haven

All Listed Sponsors
collaborator

National Institute on Drug Abuse (NIDA)

NIH

lead

Yale University

OTHER