T Cells and Pembrolizumab for Recurrent and Newly Diagnosed Glioblastoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

February 8, 2024

Primary Completion Date

April 30, 2026

Study Completion Date

January 31, 2028

Conditions
Glioblastoma MultiformeAstrocytoma, Grade IV
Interventions
BIOLOGICAL

Allogeneic cytomegalovirus-specific T cells

Allogeneic cytomegalovirus (CMV)-specific T cells generated from the blood of healthy CMV-seropositive donors

DRUG

Pembrolizumab

A humanised immunoglobulin G4 (IgG4) monoclonal antibody (mAb) specific for the programmed cell death 1 (PD-1) receptor

Trial Locations (4)

3084

NOT_YET_RECRUITING

Austin Hospital, Heidelberg

4006

RECRUITING

Newro Foundation, Bowen Hills

NOT_YET_RECRUITING

Royal Brisbane and Women's Hospital, Herston

4102

NOT_YET_RECRUITING

Princess Alexandra Hospital, Woolloongabba

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

CUREator

UNKNOWN

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

The Newro Foundation

UNKNOWN

collaborator

Royal Brisbane and Women's Hospital

OTHER_GOV

collaborator

Princess Alexandra Hospital, Brisbane, Australia

OTHER

collaborator

Austin Hospital, Melbourne Australia

OTHER

lead

Queensland Institute of Medical Research

OTHER