Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor

PHASE2CompletedINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

January 10, 2024

Primary Completion Date

September 17, 2024

Study Completion Date

October 10, 2024

Conditions
Acute Kidney Injury
Interventions
DRUG

Pantoprazole

Subjects will receive pantoprazole (40 mg iv q12H) for 2 days perioperatively (first dose after anesthesia induction and before surgical incision, second dose at chest closure, then followed by 2 doses daily (Q12hr dosing) on post operative day 1 (POD 1) for a total of 4 doses over 2 days.

DRUG

Famotidine

Subjects will receive famotidine (20 mg iv q12H) for 2 days perioperatively (first dose after anesthesia induction and before surgical incision, second dose at chest closure, then followed by 2 doses daily (Q12hr dosing) on POD 1 for a total of 4 doses over 2 days.

Trial Locations (1)

77030

The University of Texas Health Science Center at Houston, Houston

All Listed Sponsors
collaborator

Society of Cardiovascular Anesthesiologists

UNKNOWN

lead

The University of Texas Health Science Center, Houston

OTHER

NCT06154226 - Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor | Biotech Hunter | Biotech Hunter