Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2i) in Subjects With Hypertension and Chronic Kidney Disease (CKD) With Albuminuria

PHASE2CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

December 14, 2023

Primary Completion Date

February 27, 2025

Study Completion Date

April 23, 2025

Conditions
Chronic Kidney Disease
Interventions
DRUG

Lorundrostat 25mg+SGLT2i QD, Washout, Placebo+SGLT2i QD

Period 1 - Lorundrostat 25mg QD + SGLT2i QD 4 weeks; Washout - Placebo QD + SGLT2i QD 4 weeks; Period 2 - Placebo QD + SGLT2i QD 4 weeks

DRUG

Placebo QD + SGLT2i QD, Washout, Lorundrostat 25mg+SGLT2i QD

Period 1 - Placebo QD + SGLT2i QD 4 weeks; Washout - Placebo QD + SGLT2i QD 4 weeks; Period 2 - Lorundrostat 25mg + SGLT2i QD 4 weeks

Trial Locations (44)

11365

Nephrology Associates, PC, Fresh Meadows

Nephrology Associates, Fresh Meadows

22191

Mendez Center for Clinical Research, LLC, Woodbridge

27103

Nephrology Associates, Pllc - Winston-Salem, Winston-Salem

27205

Triad Internal Medicine, Asheboro

R&H Clinical Research, Katy

29203

Columbia Nephrology, Columbia

30101

American Clinical Trials Llc, Acworth

31520

Nephrology of the Golden Isles - Brunswick, Brunswick

32771

Infigo Clinical Research, Llc, Sanford

32806

Elixia Central Florida, LLC, Orlando

32896

ClinCept, LLC, Columbus

33012

Indago Research and Health Center, Hialeah

33024

Elixia Pines, LLC, Hollywood

33133

Qway Research, Coconut Grove

33401

Palm Beach Diabetes and Endocrine Specialists, PA (PBDES) - West Palm Beach Office, West Palm Beach

33614

Genesis Clinical Research - Tampa, Tampa

37408

Southeast Renal Research Institute, Chattanooga

40205

Nephrology Associates of Kentuckiana, PSC (NAK), Louisville

48341

Elixia MKC, LLC, Pontiac

64111

Kansas City Kidney Consultants (Arms, Dodge, Robinson, Wilber & Crouch, Inc.) - Kansas City, Kansas City

71101

Northwest Louisiana Nephrology, Llc - Shreveport, Shreveport

75149

Prx Research, Mesquite

75235

Dallas Nephrology Associates (Dna) - Renal Disease Research Institute (Rdri), Dallas

75237

Liberty Research Center, Dallas

75904

E T Nephrology Associates - Lufkin, Lufkin

78572

Gamma Medical Research, Inc, Mission

84790

Chrysalis Clinical Research (CCR), St. George

85016

Arizona Kidney Disease & Hypertension Centers (AKDHC) - Thomas Office, Phoenix

85306

Arizona Kidney Disease & Hypertension Centers (AKDHC) - Thunderbird Office, Glendale

90022

Academic Medical Research Institute (AMRI) - Los Angeles, Los Angeles

91324

Amicis Research Center, Northridge

91344

Amicis Research Center - Granada Hills, Granada Hills

91910

Balboa Nephrology Medical Group, Inc. (BNMG) - California Institute of Renal Research (CIRR) - Chula Vista, Chula Vista

92243

Balboa Nephrology Medical Group, Inc. (BNMG) - El Centro, El Centro

91942-3059

Balboa Nephrology Medical Group, Inc. (Bnmg) - La Mesa, La Mesa

95687-3560

Amicis Research Center - Vacaville, Vacaville

80218-1216

Colorado Kidney Care (Denver Nephrology) - Denver Office, Denver

30046-8761

Georgia Nephrology, Llc, Lawrenceville

70112-3018

Lcms Health University Medical Center New Orleans, New Orleans

02111

Tufts University School of Medicine (Tusm) - Tufts Medical Center (Tmc) (Tufts-New England Medical Center), Boston

03801

Seacoast Kidney & Hypertension Specialists - Portsmouth Office, Portsmouth

11226-1508

Suny Downstate Medical Center - Parkside Dialysis Center, Brooklyn

73116-1516

Nephrology Consultants - Oklahoma City, Oklahoma City

Sponsors
All Listed Sponsors
lead

Mineralys Therapeutics Inc.

INDUSTRY

NCT06150924 - Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2i) in Subjects With Hypertension and Chronic Kidney Disease (CKD) With Albuminuria | Biotech Hunter | Biotech Hunter