A Safety and Efficacy Study of Allogeneic CAR Gamma-Delta T Cells in Subjects with Relapsed/Refractory Solid Tumors

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

September 1, 2024

Primary Completion Date

June 30, 2027

Study Completion Date

September 30, 2027

Conditions
Solid Tumor
Interventions
BIOLOGICAL

HLA-G-CAR.BiTE allogeneic γδ T cells

"Phase I is a multiple escalating dose, single arm, open-label and 3+3 design that implemented with five cohorts: low dose for single administration, low dose for twice administrations for 2 weeks, low, middle and high dose for 4 repeated administrations for 4 weeks.~Phase IIa is a single-arm, open-label and dose-expansion study and the effective dose of CAR-positive cells will be administered to 27 evaluable subjects with TNBC, NSCLC, CRC or GBM via intravenous infusion weekly for 4 weeks."

Trial Locations (1)

404

RECRUITING

China Medical University Hospital, Taichung

All Listed Sponsors
lead

Ever Supreme Bio Technology Co., Ltd.

INDUSTRY