240
Participants
Start Date
November 30, 2023
Primary Completion Date
November 18, 2024
Study Completion Date
February 9, 2025
Pes-Guided PEEP titration
Lung recruitment is performed at each time point, involving a switch from volume-controlled (VCV) mode to pressure-controlled (PCV) mode with a pressure setting of 20 cmH2O, RR of 15 bpm, I:E ratio of 1:1, FiO2 of 0.4, and PEEP of 5 cmH2O. During lung recruitment, PEEP is gradually increased in increments of 5 cmH2O, maintained for 5 respiratory cycles until PEEP reaches 20 cmH2O and airway pressure reaches 40 cmH2O, and then maintained for 10 respiratory cycles. After lung recruitment, ventilation is adjusted based on the target PEEP. Each PEEP titration should ensure adequate muscle relaxation, volume status, and hemodynamic stability. PEEP is chosen to maintain a positive transpulmonary pressure at end-expiration (PL = PEEP - Pes). Each PEEP titration should ensure adequate muscle relaxation, volume status, and hemodynamic stability.
180 Fenglin Road, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Shanghai Geriatric Medical Center, Shanghai
Zhongshan Hospital (Xiamen), Fudan University, Xiamen
Shanghai Geriatric Medical Center
OTHER
Zhongshan Hospital (Xiamen), Fudan University
OTHER
Fudan University
OTHER
Shanghai Zhongshan Hospital
OTHER