Individualized PEEP Titration on Postoperative Pulmonary Complications

NACompletedINTERVENTIONAL
Enrollment

240

Participants

Timeline

Start Date

November 30, 2023

Primary Completion Date

November 18, 2024

Study Completion Date

February 9, 2025

Conditions
Postoperative Pulmonary ComplicationsPositive End-expiratory PressureElderlyLaparoscopic Surgery
Interventions
PROCEDURE

Pes-Guided PEEP titration

Lung recruitment is performed at each time point, involving a switch from volume-controlled (VCV) mode to pressure-controlled (PCV) mode with a pressure setting of 20 cmH2O, RR of 15 bpm, I:E ratio of 1:1, FiO2 of 0.4, and PEEP of 5 cmH2O. During lung recruitment, PEEP is gradually increased in increments of 5 cmH2O, maintained for 5 respiratory cycles until PEEP reaches 20 cmH2O and airway pressure reaches 40 cmH2O, and then maintained for 10 respiratory cycles. After lung recruitment, ventilation is adjusted based on the target PEEP. Each PEEP titration should ensure adequate muscle relaxation, volume status, and hemodynamic stability. PEEP is chosen to maintain a positive transpulmonary pressure at end-expiration (PL = PEEP - Pes). Each PEEP titration should ensure adequate muscle relaxation, volume status, and hemodynamic stability.

Trial Locations (4)

200032

180 Fenglin Road, Shanghai

Unknown

Fudan University Shanghai Cancer Center, Shanghai

Shanghai Geriatric Medical Center, Shanghai

Zhongshan Hospital (Xiamen), Fudan University, Xiamen

All Listed Sponsors
collaborator

Shanghai Geriatric Medical Center

OTHER

collaborator

Zhongshan Hospital (Xiamen), Fudan University

OTHER

collaborator

Fudan University

OTHER

lead

Shanghai Zhongshan Hospital

OTHER

NCT06150079 - Individualized PEEP Titration on Postoperative Pulmonary Complications | Biotech Hunter | Biotech Hunter