Phase II Clinical Trial to Evaluate the Safety and Efficacy of TQB2450 Injection Combined With Anlotinib Capsule and Chemotherapy in the Treatment of Immunoresistant Advanced Non-small Cell Lung Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

148

Participants

Timeline

Start Date

April 12, 2023

Primary Completion Date

December 30, 2027

Study Completion Date

December 30, 2028

Conditions
Non-small-cell Lung Cancer
Interventions
DRUG

TQB2450 +Anlotinib+Docetaxel

"TQB2450 is a humanized monoclonal antibody targeting programmed death ligand 1 (PD-L1), which prevents PD-L1 from binding to PD-1 and B7.1 receptors on the surface of T cells, restoring T cell activity and enhancing immune response. It has the potential to treat various types of tumors.~Anlotinib is a multi target receptor tyrosine kinase (RTK) inhibitor. It can inhibit VEGFR1, VEGFR2, VEGFR3, c-Kit, PDGFR β Activity.~Docetaxel is a taxane based anti-tumor drug."

DRUG

TQB2450 +Androtinib Placebo+Docetaxel

"TQB2450 is a humanized monoclonal antibody targeting programmed death ligand 1 (PD-L1), which prevents PD-L1 from binding to PD-1 and B7.1 receptors on the surface of T cells, restoring T cell activity and enhancing immune response. It has the potential to treat various types of tumors.~Androtinib Placebo Docetaxel is a taxane based anti-tumor drug."

Trial Locations (5)

222000

RECRUITING

The Second People's Hospital of Lianyungang, Lianyungang

264299

NOT_YET_RECRUITING

Weihai Municipal Hospital, Weihai

300060

RECRUITING

Tianjin Medical University Cancer Institute and Hospital, Tianjin

473000

RECRUITING

The First Affiliated Hospital of Nanyang Medical College, Nanyang

516001

NOT_YET_RECRUITING

The Central People's Hospital of Huizhou, Huizhou

All Listed Sponsors
lead

Tianjin Medical University Cancer Institute and Hospital

OTHER