A Phase Ib/II Study Of JS015 Combination Therapy in Advanced Solid Tumors

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

186

Participants

Timeline

Start Date

January 3, 2024

Primary Completion Date

November 1, 2025

Study Completion Date

January 28, 2026

Conditions
Advanced Solid Tumor
Interventions
BIOLOGICAL

JS015

JS015 will be administered intravenously (IV) on days 1 and 15 every 28 day cycle, or day 1 every 21 day cycle, based on different combined chemotherapy.

BIOLOGICAL

Toripalimab

Toripalimab will be administered intravenously (IV) on day 1 every 21 day cycle.

BIOLOGICAL

Paclitaxel

Paclitaxel will be administered intravenously (IV) on day 1 every 21 day cycle.

DRUG

Irinotecan

Irinotecan will be administered intravenously (IV) on days 1 and 15 every 28 day cycle.

DRUG

Capecitabine

Capecitabin will be administered orally twice daily from day 1 to 14 every 21 day cycle.

DRUG

Oxaliplatin

Oxaliplatin will be administered intravenously (IV) on day 1 every 21 day cycle.

BIOLOGICAL

Bevacizumab

Bevacizumab of 5mg/kg will be administered intravenously (IV) on days 1 and 15 every 28 day cycle, or7.5mg/kg on day 1 every 21 day cycle, based on different combined chemotherapy.

DRUG

Fluorouracil

Fluorouracil will be administered intravenously (IV) on days 1 and 15 every 28 day cycle.

DRUG

Leucovorin

Leucovorin will be administered intravenously (IV) on days 1 and 15 every 28 day cycle.

DRUG

Gemcitabine

Gemcitabine will be administered intravenously (IV) on days 1 and 8 every 21 day cycle.

DRUG

Albumin-Bound Paclitaxel

Albumin-bound paclitaxel will be administered intravenously (IV) on days 1 and 8 every 21 day cycle.

Trial Locations (1)

200120

RECRUITING

Shanghai East Hospital, Shanghai

All Listed Sponsors
collaborator

Sponsor GmbH

OTHER

lead

Shanghai Junshi Bioscience Co., Ltd.

OTHER