Neoadjuvant Tirellizumab Combined With Chemotherapy for Early Oral Squamous Cell Carcinoma(HNC-SYSU-004)

PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

September 1, 2023

Primary Completion Date

August 31, 2027

Study Completion Date

August 31, 2030

Conditions
Oral CancerPD-1
Interventions
DRUG

PD-1 with chemotherapy

"Tirellizumab+Carboplatin+albumin-bound paclitaxel:2 courses Tirellizumab,+Carboplatin+albumin-bound paclitaxel Tirellizumab (IV), dose= 200mg , day=1 , cycle length: 21 days. Carboplatin (IV), dose=300mg/m2, day= 1, cycle length: 21 days. albumin-bound paclitaxel (IV), dose=260mg/m2, day= 1, cycle length: 21 days.~Intervention: Drug: Tirellizumab, Carboplatin, albumin-bound paclitaxel:2 cycles Surgery:Enlarged local excision,excision with the safe margin 1.0-1.5cm away from the original tumor"

PROCEDURE

upright surgery

"Surgery:Primary resection,excision with the safe margin 1.0-1.5cm away from the original tumor~selective neck dissection:I II III region neck dissection"

Trial Locations (1)

510000

RECRUITING

Sun yat-sen memorial hospital, Guangzhou

All Listed Sponsors
lead

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

OTHER