Biomolecular Phenotyping of Lung Transplant Recipients

CompletedOBSERVATIONAL
Enrollment

80

Participants

Timeline

Start Date

February 1, 2022

Primary Completion Date

March 1, 2024

Study Completion Date

June 1, 2025

Conditions
Lung Transplant Failure
Interventions
DIAGNOSTIC_TEST

Sub-phenotyping by biomarkers concentration

Plasma will be collected at ICU admission (i.e., \< 6 hours from graft reperfusion), centrifuged (1500G for 15 min), frozen at -80°c, and then centralized at the Institutional laboratory. The following biomarkers will be assessed: Interleukin-1β, Interleukin-2, Interleukin-6, Interferon-γ, Tumor Necrosis Factor-alpha (TNF-α), chemokine (C-C motif) ligand-2 (CCL-2), Interleukin-15 (IL-15), Ferritin, and D-dimer, by a point-of-care biochip-array device (RANDOX, Multistat)

Trial Locations (1)

20122

Fondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico, Milan

All Listed Sponsors
collaborator

University of Milan

OTHER

lead

Policlinico Hospital

OTHER