Adebelizumab Combined With Chemotherapy and Radiotherapy Treat ES-SCLC

PHASE2RecruitingINTERVENTIONAL
Enrollment

51

Participants

Timeline

Start Date

October 30, 2023

Primary Completion Date

July 31, 2026

Study Completion Date

December 31, 2026

Conditions
Extensive Small Cell Lung Cancer
Interventions
DRUG

Adebelizumab+Carboplatin+Etoposide+Concurrent Radiotherapy

Eligible patients will receive the following treatment schemes: adebelizumab+carboplatin+etoposide, with one treatment cycle every three weeks. After 4-6 cycles, adebelizumab maintenance therapy combined with concurrent radiotherapy will be given, and conventional radiotherapy will be given to chest lesions (2Gy\*(20-30)f), brain (3Gy\*10f)/ bone (3Gy\*10f)/ adrenal gland. Immunotherapy is suspended during radiotherapy for chest lesions and lymph nodes in mediastinum, and immunotherapy is given 1-2 weeks after radiotherapy. Radiotherapy for other metastatic lesions can be carried out simultaneously with immunotherapy.

Trial Locations (1)

Unknown

RECRUITING

The First Affiliated Hospital of Shandong First Medical University, Jinan

All Listed Sponsors
lead

Qianfoshan Hospital

OTHER