Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis

NARecruitingINTERVENTIONAL
Enrollment

192

Participants

Timeline

Start Date

April 1, 2025

Primary Completion Date

March 31, 2029

Study Completion Date

July 31, 2029

Conditions
Osteonecrosis of the Femoral HeadAvascular Necrosis of the Femoral Head
Interventions
PROCEDURE

Core Decompression

Standard core decompression procedure is performed by drilling into the necrotic bone of the femoral head. A sham bone marrow aspiration involves advancing a needle to the iliac crest (no bone penetration, no bone marrow aspiration) through a small skin incision.

PROCEDURE

Core Decompression Procedure with Autologous Bone Marrow Aspirate Concentrate

This involves bone marrow aspiration, concentrating the bone marrow aspirate, and injecting 6 milliliters of bone marrow aspirate concentrate into the necrotic femoral head through an opening created by the core decompression.

Trial Locations (12)

11016

RECRUITING

NYU Langone Health Orthopedic Hospital, New York

19104

RECRUITING

University of Pennsylvania, Philadelphia

21215

RECRUITING

Sinai Hospital of Baltimore, Baltimore

21224

RECRUITING

Johns Hopkins University, Baltimore

22903

RECRUITING

University of Virginia, Charlottesville

27560

NOT_YET_RECRUITING

Duke University, Durham

55455

RECRUITING

University of Minnesota, Minneapolis

55905

RECRUITING

Mayo Clinic, Rochester

90033

RECRUITING

University of Southern California, Los Angeles

94063

RECRUITING

Stanford University, Stanford

441195

RECRUITING

Cleveland Clinic, Cleveland

02115

NOT_YET_RECRUITING

Brigham and Women's Hospital, Boston

All Listed Sponsors
collaborator

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NIH

lead

Johns Hopkins University

OTHER