A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

February 1, 2024

Primary Completion Date

November 30, 2027

Study Completion Date

November 30, 2027

Conditions
Esophageal CancerGastric AdenocarcinomaHER2 Gene Mutation
Interventions
DRUG

Pembrolizumab

Pembrolizumab will be administered on an every 3-week dosing schedule

DRUG

Trastuzumab

Trastuzumab will be administered on an every 3-week dosing schedule

DRUG

Oxaliplatin

Oxaliplatin every 3 weeks, +/-7 days

DRUG

Capecitabine

Capecitabine twice daily on days 1 to 14 every 3 weeks or 5-FU on days 1 to 5 every 3 weeks

DRUG

5-Fluorouracil

5-Fluorouracil administered as a 24 hour IV continuous infusion once every 2 weeks

DRUG

Docetaxel

Docetaxel administered intravenously once every 2 weeks.

Trial Locations (10)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York

10604

RECRUITING

Memorial Sloan Kettering Westchester (Limited Protocol Activities), Harrison

11553

RECRUITING

Memorial Sloan Kettering Nassau (Limited Protocol Activities), Uniondale

11725

RECRUITING

Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity), Commack

19104

RECRUITING

University of Pennsylvania (Data Collection Only), Philadelphia

77030

RECRUITING

MD Anderson Cancer Center (Data Collection Only), Houston

02114

RECRUITING

Massachusetts General Hospital (Data Collection Only), Boston

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge

07748

RECRUITING

Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Memorial Sloan Kettering Cancer Center

OTHER