A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 Following Single and Multiple Ascending Doses Via Oral Administration to Healthy Participants

PHASE1CompletedINTERVENTIONAL
Enrollment

95

Participants

Timeline

Start Date

November 7, 2023

Primary Completion Date

December 4, 2024

Study Completion Date

December 4, 2024

Conditions
Healthy Participants
Interventions
DRUG

AZD4144 Part A

Part A: Participants will be administered a single oral dose on Day 1.

DRUG

AZD4144 Part B

Part B: Participants will be administered a single dose on Day 1, and repeated dosing will commence from Day 4 until Day 11 (inclusive) and a single dose on Day 12.

DRUG

Placebo Part A

Part A: Participants will be administered a single oral dose of matching placebo on Day 1.

DRUG

Placebo Part B

Part B: Participants will be administered a single dose of matching placebo on Day 1, and repeated dosing will commence from Day 4 until Day 11 (inclusive) and a single dose on Day 12.

Trial Locations (2)

21225

Research Site, Brooklyn

91206

Research Site, Glendale

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Parexel

INDUSTRY

lead

AstraZeneca

INDUSTRY