A Study of Venetoclax in Combination With Isatuximab and Dexamethasone for Relapsed/Refractory Multiple Myeloma

PHASE2RecruitingINTERVENTIONAL
Enrollment

39

Participants

Timeline

Start Date

June 20, 2024

Primary Completion Date

April 30, 2026

Study Completion Date

December 31, 2027

Conditions
Multiple Myeloma in RelapseMultiple Myeloma, Refractory
Interventions
DRUG

Venetoclax

All subjects in Dose Level 0 will receive 1) venetoclax, PO, at 400 mg every day (QD) on Days 1-28 of a 28-day cycle, 2) dexamethasone 40 mg IV, once weekly on Days 1, 8, 15, and 22 of a 28-day cycle; and 3) isatuximab 10mg/kg, IV, on Days 1, 8, 15, and 22 of the first 28-day cycle, and then Days 1 and 15 during subsequent 28-day cycles.

Trial Locations (2)

68130

RECRUITING

Nebraska Cancer Specialists, Omaha

90069

RECRUITING

Berenson Cancer Center, West Hollywood

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Oncotherapeutics

INDUSTRY