A Study of HS-10241 Combined With Almonertinib Versus Platinum-based Chemotherapy in Treatment of Advanced NSCLC With MET Amplification After Failure of EGFR-TKI Therapy

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

314

Participants

Timeline

Start Date

December 30, 2023

Primary Completion Date

December 30, 2024

Study Completion Date

February 28, 2025

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

HS-10241+ Almonertinib

HS-10241 300mg twice daily (BID) combined with Almonertinib 110mg once daily (QD) orally, for every cycle of 21 days until disease progression or other criteria for treatment discontinuation will be met.

DRUG

Pemetrexed + Cisplatin /Carboplatin

"The standard chemotherapy treatment of cisplatin/carboplatin combined with pemetrexed for 4\~6 cycles (every 3 weeks).~Participants will continue receive pemetrexed monotherapy until disease progression or other criteria for treatment discontinuation will be met."

All Listed Sponsors
lead

Jiangsu Hansoh Pharmaceutical Co., Ltd.

INDUSTRY

NCT06110663 - A Study of HS-10241 Combined With Almonertinib Versus Platinum-based Chemotherapy in Treatment of Advanced NSCLC With MET Amplification After Failure of EGFR-TKI Therapy | Biotech Hunter | Biotech Hunter