Neoadjuvant Camrelizumab With Dalpiciclib for Resectable Head and Neck Squamous Cell Carcinomas

PHASE1RecruitingINTERVENTIONAL
Enrollment

6

Participants

Timeline

Start Date

October 31, 2023

Primary Completion Date

October 31, 2024

Study Completion Date

October 31, 2025

Conditions
Head and Neck Squamous Cell Carcinoma
Interventions
DRUG

Camrelizumab

Camrelizumab will be given at at a dose of 200 mg intravenously every three weeks on day 1 of a planned 21-day cycle, and two doses before surgery

DRUG

Dalpiciclib 100mg

Dalpiciclib will be given at a dose of 100 mg every day orally with three weeks on and one week off. Four weeks is a cycle and it will be given for two cycles.

DRUG

Dalpiciclib 150mg

Dalpiciclib will be given at a dose of 150 mg every day orally with three weeks on and one week off. Four weeks is a cycle and it will be given for two cycles.

Trial Locations (1)

610041

RECRUITING

West China Hospital, Sichuan University, Chengdu

All Listed Sponsors
lead

West China Hospital

OTHER