Iberdomide and Daratumumab As Maintenance Therapy After an Autologous Stem Cell Transplant for Multiple Myeloma

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

December 21, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
Multiple Myeloma
Interventions
DRUG

Iberdomide

Iberdomide 1.0mg daily for days 1-21 of a 28-day cycle, an increase to 1.3 mg daily on Day 1-21 of a 28-day cycle is allowed at cycle 4 or higher if the 1.0 mg dose was well tolerated.

DRUG

Daratumumab/rHuPH20 Co-formulation

"Daratumumab/rHuPH20 will be dosed as follows:~* Daratumumab/rHuPH20 1800 mg SC days 1, 8, 15, 22 (28-day cycle; cycles 1-2)~* Daratumumab/rHuPH20 1800 mg SC days 1, 15 (28-day cycle; cycles 3-6)~* Daratumumab/rHuPH20 1800 mg SC day 1 (28-day cycle; cycles 7-26)"

Trial Locations (2)

48201

RECRUITING

Karmanos Cancer Institute, Detroit

48910

RECRUITING

KCI at McLaren Greater Lansing, Lansing

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Janssen Pharmaceuticals

INDUSTRY

collaborator

Multiple Myeloma Research Consortium

NETWORK

lead

Barbara Ann Karmanos Cancer Institute

OTHER