Evaluate the Safety, Tolerability, Pharmacodynamics and Efficacy of CNP-106 in Subjects With Myasthenia Gravis

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

May 30, 2024

Primary Completion Date

June 30, 2026

Study Completion Date

August 31, 2026

Conditions
Myasthenia GravisGeneralized MyastheniaAChR Myasthenia GravisMuSK MG
Interventions
DRUG

CNP-106

CNP-106 is comprised of an antigenic AChR Peptide Pool (\~1 μg of each AChRα and AChRε peptide comprising AChR Peptide Pool Drug Substance per mg particles) dispersed within a negatively charged (-30 to -60 mV) polymer matrix of PLGA (Poly (DL-lactide-co-glycolide, 50:50 acid-end group)) particles (400-800 nm in size).

OTHER

Placebo

CNP-106 Placebo

Trial Locations (17)

23298

NOT_YET_RECRUITING

Virginia Commonwealth University, Richmond

29425

NOT_YET_RECRUITING

Medical University of South Carolina, Charleston

33173

RECRUITING

Atlantis Research, Miami

RECRUITING

Quantix Research, LLC, Miami

33612

RECRUITING

University of South Florida, Tampa

43221

NOT_YET_RECRUITING

Ohio State University Wexner Medical Center, Colombus

48126

RECRUITING

Insight Research Institute, Dearborn, Dearborn

60608

RECRUITING

Insight Hospital and Medical Center, Chicago

65211

RECRUITING

University of Missouri, NextGen Precision Health, Columbia

66160

NOT_YET_RECRUITING

University of Kansas Medical Center, Kansas City

77030

RECRUITING

Nerve and Muscle Center of Texas, Houston

77054

RECRUITING

Prolato Clinical Research Center, Houston

85013

RECRUITING

Barrow Neurological Institute, Phoenix

85028

NOT_YET_RECRUITING

Neuromuscular Clinic and Research Center, Phoenix

92835

RECRUITING

Infusion for Health, Brea

92868

RECRUITING

University of California, Irvine, Orange

06516

RECRUITING

Yale University, New Haven

All Listed Sponsors
lead

COUR Pharmaceutical Development Company, Inc.

INDUSTRY

NCT06106672 - Evaluate the Safety, Tolerability, Pharmacodynamics and Efficacy of CNP-106 in Subjects With Myasthenia Gravis | Biotech Hunter | Biotech Hunter