Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

March 6, 2024

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2029

Conditions
Pancreatic Ductal AdenocarcinomaNon-Small Cell Lung CancerColorectal CancerSolid TumorKRAS G12V
Interventions
DRUG

AFNT-211

Engineered TCR T-Cell

Trial Locations (10)

10016

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York

10065

Memorial Sloan Kettering Cancer Center, New York

37203

Sarah Cannon Research Institute, Nashville

53792

University of Wisconsin Carbone Cancer Center, Madison

77030

MD Anderson Cancer Center, Houston

90033

USC Norris Comprehensive, Los Angeles

90095

University of California Los Angeles Department of Medicine, Los Angeles

97213

Providence Cancer Institute Franz Clinic, Portland

98109

Fred Hutchinson Cancer Center, Seattle

06511

Yale New Haven Hospital, New Haven

Sponsors
All Listed Sponsors
lead

Affini-T Therapeutics, Inc.

INDUSTRY