NCT06103396View on ClinicalTrials.gov

Treatment of Nonunion Fractures With Mesenchymal Stromal Cells (MSCs)

PHASE1/PHASE2Enrolling by invitationINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

January 30, 2018

Primary Completion Date

January 30, 2022

Study Completion Date

December 30, 2024

Conditions
Pseudoarthrosis of BonePseudarthrosisNon Union FractureNonunion Bone Fracture
Interventions
BIOLOGICAL

Transplantation of autologous MSCs in nonunion fracture

"At surgery, fibrotic tissue is removed from the nonunion sites. MSCs/Col/PRP clots are implanted in the site of nonunion.~Patients received conventional orthopedic treatment as they needed (osteotomy, external and/or internal fixation systems, etc.)"

BIOLOGICAL

Transplantation of allogeneic MSCs in nonunion fracture

"At surgery, fibrotic tissue is removed from the nonunion sites. MSCs/Col/PRP clots are implanted in the site of nonunion.~Patients received conventional orthopedic treatment as they needed (osteotomy, external and/or internal fixation systems, etc.)"

Trial Locations (1)

1204

Instituto Venezolano de Investigaciones Cientificas, Caracas

All Listed Sponsors
collaborator

Hospital Central Dr. Plácido D. Rodriguez Rivero

UNKNOWN

collaborator

Instituto Autónomo Hospital Universitario de la Universidad de Los Andes

UNKNOWN

lead

Instituto Venezolano de Investigaciones Cientificas

OTHER