Personalized Vaccination in Fusion+ Sarcoma Patients (PerVision)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

September 19, 2023

Primary Completion Date

June 30, 2027

Study Completion Date

September 30, 2027

Conditions
Ewing SarcomaRhabdomyosarcomaSynovial Sarcoma
Interventions
BIOLOGICAL

Peptide vaccine IPX

"Peptide vaccine is a combination of~1. class II peptide spanning the sarcoma-specific fusion-breakpoint (fusion-peptide)~2. class-II neopeptide based on a patient-individual nonsynonymous mutation with a high immunogenicity (mutation-based neopeptide).~3. control peptide derived from Survivin.~4. adjuvant: toll like receptor (TLR) 1/2 ligand XS15."

Trial Locations (4)

45147

NOT_YET_RECRUITING

Pediatrics III, West German Cancer Centre, University Hospital, Essen

60590

NOT_YET_RECRUITING

Universitätsklinikum, Klinik für Kinder- und Jugendmedizin, Frankfurt am Main

72076

RECRUITING

University Children's Hostpital, Tübingen

79106

NOT_YET_RECRUITING

Zentrum für Kinder- und Jugendmedizin, Universitätsklinikum, Freiburg im Breisgau

All Listed Sponsors
collaborator

Deutsches Konsortium fürTranslationale Krebsforschung (DKTK)

UNKNOWN

collaborator

Cooperative Ewing Sarkom Studiengruppe

UNKNOWN

collaborator

Cooperative Weichteilsarkom Study Group

OTHER

lead

University Hospital Tuebingen

OTHER