Modulating Surgery-Induced Blood-Brain Barrier Disruption in Elderly

NARecruitingINTERVENTIONAL
Enrollment

108

Participants

Timeline

Start Date

October 25, 2023

Primary Completion Date

November 30, 2024

Study Completion Date

December 31, 2024

Conditions
Delirium, Postoperative
Interventions
DRUG

Dexmedetomidine Injection [Precedex]

The study drugs(dexmedetomidine 80 μg/20 mL) will be prepared with 20 mL syringe and marked as 'trial drug', which are identical in appearance with control and active comparator. In order to avoid anaesthesiologists' speculation about the randomised assignment, the study drugs will be infused at the same rate.

DRUG

Lidocaine IV

The study drugs(lidocaine 400 mg/20 mL) will be prepared with 20 mL syringe and marked as 'trial drug', which are identical in appearance with control and active comparator. In order to avoid anaesthesiologists' speculation about the randomised assignment, the study drugs will be infused at the same rate.

DRUG

normal saline

The study drugs(normal saline) will be prepared with 20 mL syringe and marked as 'trial drug', which are identical in appearance with control and active comparator. In order to avoid anaesthesiologists' speculation about the randomised assignment, the study drugs will be infused at the same rate.

Trial Locations (1)

06351

RECRUITING

Samsung Medical Center, Seoul

All Listed Sponsors
lead

Samsung Medical Center

OTHER