Bevacizumab in Combination With Sintilimab Versus Transcatheter Arterial Chemoembolization for the Treatment of Intermediate Stage Hepatocellular Carcinoma (Beyond Up-To-Seven Criteria)

PHASE2RecruitingINTERVENTIONAL
Enrollment

88

Participants

Timeline

Start Date

March 2, 2023

Primary Completion Date

July 25, 2025

Study Completion Date

July 25, 2025

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Bevacizumab combined with Sintilimab

Bevacizumab combined with sintilimab, sindilizumab 200 mg IV d1, Q3W, combined with bevacizumab 15 mg/kg IV d1, Q3W treatment, treatment continued until disease progression, development of intolerable toxic reactions

PROCEDURE

Transcatheter arterial chemoembolization

Transcatheter arterial chemoembolization, patients were treated with cTACE, and the efficacy was assessed by repeat CT/MRI 1 month after the initial treatment, and if the tumor still had arterial phase enhancement, TACE treatment could be supplemented until treatment failure and withdrawal of consent.

Trial Locations (1)

510000

RECRUITING

Sun Yat-Sen University Cancer Center, Guangzhou

All Listed Sponsors
lead

Sun Yat-sen University

OTHER