A Phase I/II Study to Evaluate AZD5851 in GPC3+ Advanced/Recurrent Hepatocellular Carcinoma

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

94

Participants

Timeline

Start Date

December 14, 2023

Primary Completion Date

December 13, 2027

Study Completion Date

December 13, 2027

Conditions
Hepatocellular Carcinoma
Interventions
BIOLOGICAL

AZD5851

"Subjects will undergo leukapheresis to isolate peripheral blood mononuclear cells (PBMCs) to produce AZD5851.~During AZD5851 production, subjects may receive bridging therapy for disease control. Upon successful generation of AZD5851 product, subjects will receive treatment with AZD5851 therapy.~Study treatment will include lymphodepleting chemotherapy followed by one dose of AZD5851 administered by intravenous (IV) infusion."

Trial Locations (20)

10065

Research Site, New York

15237

Research Site, Pittsburgh

19104

Research Site, Philadelphia

20007

Research Site, Washington D.C.

30322

Research Site, Atlanta

32224

Research Site, Jacksonville

43210

Research Site, Columbus

55905

Research Site, Rochester

66205

Research Site, Westwood

85054

Research Site, Phoenix

91010

Research Site, Duarte

92868

Research Site, Orange

94143

Research Site, San Francisco

97239

Research Site, Portland

07601

Research Site, Hackensack

104-0045

Research Site, Chūōku

227-8577

Research Site, Kashiwa

606-8507

Research Site, Kyoto

589-8511

Research Site, Osakasayama-shi

03080

Research Site, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY