NCT06078709 - Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

November 20, 2023

Primary Completion Date

May 30, 2026

Study Completion Date

November 30, 2026

Conditions

Clinical Stage I Esophageal Adenocarcinoma AJCC v8Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage II Esophageal Adenocarcinoma AJCC v8Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage III Esophageal Adenocarcinoma AJCC v8Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

Interventions

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT and PET/CT scan

PROCEDURE

Endoscopic Ultrasound

Undergo EUS

PROCEDURE

Esophagogastroduodenoscopy

Undergo EGD

DRUG

Fluorouracil

Given IV

RADIATION

Hypofractionated Radiation Therapy

Undergo hypofractionated radiation therapy

DRUG

Leucovorin Calcium

Given IV

DRUG

Oxaliplatin

Given IV

PROCEDURE

Positron Emission Tomography

Undergo PET and PET/CT scan

OTHER

Survey Administration

Ancillary studies

DRUG

Docetaxel

Given IV

BIOLOGICAL

Durvalumab

Given IV

Trial Locations (3)

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

85259

NOT_YET_RECRUITING

Mayo Clinic in Arizona, Scottsdale

32224-9980

ACTIVE_NOT_RECRUITING

Mayo Clinic in Florida, Jacksonville