Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis

PHASE4RecruitingINTERVENTIONAL
Enrollment

3,720

Participants

Timeline

Start Date

November 21, 2023

Primary Completion Date

October 31, 2028

Study Completion Date

December 31, 2028

Conditions
Sinus InfectionAcute Sinusitis
Interventions
DRUG

Amoxicillin/Clavulanate Potassium 875 MG-125 MG Oral Tablet

Amoxicillin/clavulanate, oral, 875mg/125mg twice daily for 7 days

DRUG

Placebo

Placebo for amoxicillin/clavulanate, oral, twice daily for 7 days

DRUG

Budesonide nasal spray

Budesonide nasal spray, 32 mcg per spray, 2 sprays per nostril, once per day

OTHER

C-reactive protein

Measurement of C-reactive protein level in capillary blood

Trial Locations (7)

17033

RECRUITING

Penn State College of Medicine, Hershey

20007

RECRUITING

Georgetown University Medical Center, Washington D.C.

20782

NOT_YET_RECRUITING

MedStar Health Research Institute, Hyattsville

23219

RECRUITING

Virginia Commonwealth University, Richmond

53705

RECRUITING

University of Wisconsin-Madison, Madison

90095

RECRUITING

University of California, Los Angeles, Los Angeles

98195

RECRUITING

University of Washington, Seattle

Sponsors
All Listed Sponsors
collaborator

Patient-Centered Outcomes Research Institute

OTHER

collaborator

Medstar Health Research Institute

OTHER

collaborator

Penn State College of Medicine

UNKNOWN

collaborator

University of Washington

OTHER

collaborator

Virginia Commonwealth University

OTHER

collaborator

University of California, Los Angeles

OTHER

collaborator

University of Wisconsin, Madison

OTHER

lead

Daniel Merenstein

OTHER